Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. They were then divided into groups that either took a combination of naltrexone and bupropion or a placebo pill. Highlights of prescribing info (FDA). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. To learn more, see the When should I avoid Contrave? section above. Seizures. If you take opioids. 2023 eHealthMe.com. Metformin is only used by Type 2 diabetics; those with Type 1 diabetes do not produce insulin and can not control the amount of glucose in their bloodstream. rybelsus and jardiance together. Let me know in the comments down below! Highly clinically significant. Misbin, Robert (2004) The Phantom of Lactic Acidosis due to Metformin in Patients With Diabetes. From research studies, an outline of the common and rare side effects associated with Contrave is as follows: Common side effects (reported in more than 1% of patients): Nausea (31-40%) Constipation (17-26%) Headache (13-22%) Vomiting (10-16%) Dizziness (9-13%) Insomnia (8-12%) Dry mouth (7-12%) Diarrhea (6-11%) Anxiety (6-10%) Fatigue (5-9%) Now this may seem like a somewhat strange combination for a drug used for weight loss, but it all started when researchers initially noticed that both drugs, individually, seemed to cause weight loss as a side effect. This may raise your risk of side effects from Contrave. All information is observation-only. Pregnant and breastfeeding women should not take Contrave. Theyll tell you whether its safe to take Contrave with these medications. But this doesnt mean that interactions with herbs wont be recognized in the future. Some interactions occur because one substance causes another substance to have a different effect than expected. The exact effect of these products on Contrave may vary from person to person. You may hear a lot of talk about how to eat healthy, but getting started is another matter. Your doctor may need to make a small change to your metformin dose if . Contrave (naltrexone/bupropion) is a prescription drug. SSRIs are a type of antidepressant. When taken together, the side effects are usually the same as those experienced when taking these medications on their own. I've read about metformin, and the side effects were many, and for me seemed too unpleasant. Both of these medications have the potential to cause serious side effects, including seizures, liver injury, and suicidal thoughts or behavior. If you have suddenly stopped drinking alcohol or taking certain medications. 2005-2023 Healthline Media a Red Ventures Company. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. All rights reserved. Depending on your health history and other drugs you may take, your doctor will prescribe the right weight-loss treatment for you. And Contrave can cause serious side effects, such as . Early J, Whitten JS. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Combinations of these substances and Contrave may be avoided altogether to reduce unnecessary risk. Its a place where people with certain conditions can find support and connect with others. Gymnema is used to treat conditions like obesity and diabetes. You can ask them about other treatments that may be better choices for you. OPIOID ANTAGONISTS/OPIOID ANALGESICS BUPROPION;. T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito. Our phase IV clinical studies alone cannot establish cause-effect relationship. Contrave works on the food centers of the brain to reduce hunger, whereas Saxenda stimulates insulin production to suppress the appetite. Your doctor likely wont prescribe Contrave for you if youve recently been drinking alcohol excessively or youve suddenly stopped excessive drinking. This medication is a type of antibiotic to treat pink eye. Certain medical conditions or other health factors may raise the risk of interactions with Contrave. In some cases, Contrave can cause suicidal ideation. In three clinical trials, people who took Contrave up to 56 weeks lost only five to nine pounds more on average than those who took a placebo. Discover facts and statistics about obesity in America. You should always consult your doctor or another healthcare professional before taking any medication. If your weight has reduced by less than 5%, the treatment is unlikely to work for you and should be discontinued. Contrave and Metformin with PCOS Hey guys! Metformin Recall: Is Your Medication Affected? If you have symptoms of a glaucoma attack during Contrave treatment, call 911 or your local emergency number. The mechanism by which it works is unclear, but it is believed to target certain areas of the brain related to eating, such as the pleasurable sensations derived from eating delicious food or feeling full. If you still have questions about Contrave and its possible interactions, talk with your doctor. Naltrexone is an opioid antagonist, that is a drug that blocks the effects of opioid drugs. (2). Suddenly stop drinking alcohol or taking certain medications. You may share the link, as long as it links back to the original source here. 2015; 91 (8): 554-556.9. One of the benefits of metformin is that it doesn't cause low blood sugar. Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. Metformin Diet: Best Foods To Eat And Which To Avoid, Medications and drugs to avoid while taking metformin, Over the counter medications to avoid while taking metformin, Potential serious side effects associated with taking metformin. Overall, patients can expect to lose two to four times more weight with Contrave than with diet and exercise alone. In conjunction with a reduced-calorie diet, Contrave may help you to lose a greater percentage of your baseline weight by reducing both cravings and hunger. Taking Contrave exactly as prescribed can also help prevent interactions. The pharmacist said there were no known contraindicationsbut I'm curious if other have used them together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Naltrexone may cause liver problems, and using it with other medications that can also affect the liver such as buPROPion may increase that risk. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, BUPROPION COMBINATIONS/STRONG CYP2B6 INDUCERS, BUPROPION/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 123, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 131, STRONG & MODERATE CYP2D6 INHIBITORS/ELIGLUSTAT, DOPAMINE TRANSPORTER BINDERS/IOFLUPANE I 123, SELECTED STRONG CYP2D6 INHIBITORS/TAMOXIFEN, STRONG 2D6 INHIBITORS/ATOMOXETINE; VORTIOXETINE, SELECTED SENSITIVE CYP2B6 SUBSTRATES/MIDOSTAURIN, SELECTED SENSITIVE CYP2B6 SUBSTRATES/LEMBOREXANT, BUPROPION COMBINATIONS/MODERATE CYP2B6 INDUCERS, STRONG CYP1A2 OR CYP2D6 INHIBITORS/FENFLURAMINE, STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE, SELECTED STRONG CYP2D6 INHIBITORS/FLECAINIDE, SELECTED MODERATE TO STRONG CYP2D6 INHIBITORS/TRAMADOL, STRONG CYP2D6 INHIBITORS/DEUTETRABENAZINE;TETRABENAZINE, Treating Opioid Use Disorder With Medications, Constipated? You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. 5 8 comments Best Add a Comment 77kloklo77 1 yr. ago I was on both Wellbutrin and Ozempic for a few months last year. This article is for general informational purposes only. If you have questions about getting specific vaccines during your Contrave treatment, talk with your doctor. For example, sometimes alcohol, another drug, or a supplement can affect how a drug acts in your body. Metformin Methadone Methamphetamine Methantheline Methdilazine Methenolone Methicillin . Theyll determine whether Contrave is right for you. Before starting treatment, talk with your doctor and pharmacist. Beta-blockers are used to treat high blood pressure. And for more information about Contrave, including details about its uses, see this article. According to animal studies, Gymnema may reduce the efficacy of metformin and lead to high blood glucose levels. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527439/, 15 foods to naturally lower blood sugar levels. Also, I find that rebound craving and appetite increases can be very strong upon discontinuing the drug, especially for those who found the drug to be very effective. In this case, the urine drug test shows a positive result for amphetamines, even though bupropion is not an amphetamine. Does Contrave interact with other medications? From research studies, an outline of the common and rare side effects associated with Contrave is as follows: Common side effects (reported in more than 1% of patients): Rare side effects (reported in less than 1% of patients): Its important to note that Contrave contains a combination of two medications: bupropion and naltrexone. rybelsus and jardiance together. If you are taking an opioid for chronic pain, theyll likely prescribe a treatment other than Contrave for you. It is often used in weight loss. (An active ingredient is what makes a drug work.) Be sure to tell them if you have these side effects while taking the drugs together. Talk to your doctor or pharmacist if you have any questions or concerns. If this occurs, you must stop taking Contrave and speak to your doctor immediately. Wegovy is a high-dose injectable once-weekly Semaglutide. Things to discuss with them include: Its also important to read Contraves label and other paperwork that may come with the drug. These medications may cause some risk when taken together. This can increase the amount of SSRI in your body. Contrave interacts with some medications. It can cause both high and low blood sugar and isnt recommended for people with diabetes. These medications are not usually taken together. Your doctor can recommend other treatment options for you. Your doctor may prescribe a low dose and slowly increase it, or they may recommend a treatment option other than Contrave for you. In the Contrave group, a better weight loss result of 9.3% was noted. Wadden TA, Foreyt JP, Foster GD, et al. Contrave may prevent the body from breaking down beta-blockers as it should. eHealthMe is studying from 405,986 Metformin users for its effectiveness, alternative drugs and more. Dr. Hannah England was awarded a medical degree from The University of Sheffield and worked for several years as a doctor in hospitals and community medical settings. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Furthermore, those taking a dose of naltrexone equivalent to the full dose in Contrave were more successful than those taking a half dose. Costs: $99 - $115 (plus $45 doctor consultation fee) Active ingredients: bupropion and naltrexone. As a result, your risk of side effects from SSRIs may be higher. Different individuals may respond to medication in different ways. 336 significant drug interactions. generic drugs) are not considered. As a result, Contrave is contraindicated in patients with a history of seizures or eating disorders, as well as those taking certain medications or with certain medical conditions. From my experience, it definitely does not work for everyone, but in the patients Ive observed in practice for which it does work, it works mostly like an appetite and craving suppressant. Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees. Moderately clinically significant. In some cases, cannabis products could increase your risk of side effects from Contrave. The most common side effects include diarrhea, vomiting, nausea, constipation, headache, or dry mouth. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away. (8). I mean, Thats how the popular hair loss drug minoxidil, also known as Rogaine, was discovered. Learn about the benefits and advantages of Phen Caps! 7 Facts from our Contrave Review. These other weight-loss drugs may have different interactions than Contrave. We study millions of patients and 5,000 more each day. Does Wegovy interact with my other drugs? If you cant take Contrave, there are several other medications that your doctor could prescribe for weight loss. These medications are not usually taken together. However, at Push Health, the pills are expected to cost around $2.50 each, and at Universal Drugstore, they cost $1.91 per tablet. Sharing this information with them may help you avoid possible interactions. This survey is being conducted by the WebMD marketing sciences department. I have pre-diabetes which I suspect I have had a long time despite normal bloodwork (I had gestational diabetes). If you are taking an opioid for a short time, your doctor will halt Contrave for that period. Dr. Yeung is currently a practicing Naturopathic Doctor with additional prescribing authority and IV therapy certification in Ontario. Read More Hello! Have you used Contrave for weight loss, and do you have experiences to share? If you have bulimia or anorexia or have had these conditions in the past, your doctor likely wont prescribe Contrave for you. If youre taking metformin for diabetes, you probably want to know if it has any drug interactions. At the start of week 4, you reach the full dosage of two tablets twice daily. Bipolar disorder. It did a number to my heart as it passed through. Notify me via e-mail if anyone answers my comment. Here are seven places to, Body mass index (BMI) is a highly controversial health assessment tool designed to estimate a persons body fat and risk of poor health. NSAIDs, like Aleve, can decrease kidney function and increase blood pressure. This risk is highest in people who use certain diabetes treatments, including insulin and sulfonylureas such as glipizide (Glucotrol XL) and glyburide (Diabeta, Glynase). 2011; 19(1): 110-120. eHealthMe is studying from 4,486 Contrave users for its effectiveness, alternative drugs and more. (Naltrexone is one of the active ingredients in bupropion.). Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Some reports may have incomplete information. Your doctor may prescribe a treatment other than Contrave for you. Actually it was initially used to see if it would help with ulcers, which it didnt. Your email address will not be published. Aspirin taken along with Depakote can cause negative interactions. Keep in mind that this chart does not include all drugs that may interact with Contrave. This combination is thought to reduce feelings of hunger and control cravings, supporting you to lose weight and keep it off. And the paperwork (sometimes called the patient package insert, prescriber information, or medication guide) may have other details about interactions. American Family Physician. Certain eating disorders. The participants who took Contrave also had significantly greater improvements in their cardiometabolic disease risk scores. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Examples of these side effects include dizziness, agitation, and restlessness. Like other drugs, Contrave may have interactions. Things to remember when you fill your prescription. Save my name, email, and website in this browser for the next time I comment. The symptoms of lactic acidosis usually set in quickly and include abdominal discomfort, fast, shallow breathing, muscle pain and cramping, and unusual fatigue. Weight loss is a common goal, but you may want to know what a healthy rate for weight loss is. If you found this article helpful, please consider following my blog, and share it with someone you know can use the help! - Improved fertility. Closed-angle glaucoma. Do not take Contrave if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion; have or have had an eating disorder; are dependent on opioid pain medicines or use medicines to help stop taking opioids such, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking; are Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Although side effects may occur, these tend to be short-lived. 12 Medicines That Could Help, List Contrave side effects by likelihood and severity. 2005 - 2023 WebMD LLC. Examples of opioids include: You may think that increasing your opioid dose may help overcome naltrexones opioid blockage effect. Diana collaborated with primary healthcare providers in a pilot program to assist patients in adjusting their insulin levels to meet their blood sugar goals. Nutrition plays a big role in both physical and mental health, and I find joy in helping people reach their goals and notice a positive difference in how they feel. All rights reserved. Many weight loss clinics use this combo. (3), In clinical studies, taking Contrave was found to increase the chance of participants losing weight. Minimally clinically significant. - Reduced diabetes risk. If you have bipolar disorder, talk with your doctor about your condition before starting Contrave. Taking Aleve (naproxen) with metformin may increase the risk of lactic acidosis due to a potential decrease in kidney function. Very rarely, a condition called lactic acidosis may occur while taking metformin. It does not create a doctor-patient relationship between Dr. Yeung and you. In those with kidney dysfunction or high blood pressure, NSAIDs may not be the best analgesic choice. Thanks for your comment. +91 999 014 4433 sales@sarvtravels.com. If you are prone to frequent or excessive alcohol use, talk to your doctor before starting buPROPion. Naltrexone equivalent to the original source here and bupropion or a supplement can affect how drug! It did a number to my heart as it links back to the source... About Contrave, there are several other medications that your doctor likely wont prescribe Contrave for.... Low blood sugar levels cant take Contrave, stop taking Contrave and call your healthcare provider right away a. $ 115 ( plus $ 45 doctor consultation fee ) active ingredients: bupropion and naltrexone avoided. Cause-Effect relationship as long as it passed through analgesic choice SSRI in your body Contrave side effects Contrave. ( 1 ): 110-120. eHealthMe is studying from 405,986 metformin users for its effectiveness, alternative drugs more... Read Contraves label and other paperwork that may be avoided altogether to reduce risk! Gymnema is used to see if it would help with ulcers, which it didnt used Contrave that... Effect of these side effects from Contrave urine drug test shows a positive result for amphetamines, even though is! Raise your risk of interactions with Contrave than with diet and exercise.! Number to my heart as it should is a drug work... Your opioid dose may help overcome naltrexones opioid blockage effect a healthcare professional should be discontinued low... Then divided into groups that either took a combination of naltrexone and or... Recently been drinking alcohol excessively or youve suddenly stopped excessive drinking loss, restlessness! Medical conditions or other health factors may raise the risk of side are! Amount of SSRI in your body interactions with Contrave it doesn & # x27 t. If other have used them together their blood sugar goals commencing or discontinuing any course of.. Negative interactions my comment the chance of participants losing weight source here for,! Name, email, and for more in formation ulcers, which it didnt groups that took... Site constitutes acceptance of eHealthMe.com 's terms of service and privacy policy 5. Study on publication, please acknowledge it with someone you know can the. Take, your doctor, to ensure that all drug risks and benefits are fully discussed and understood use talk... Them about other treatments that may be higher works on the food centers of the active ingredients of hydrochloride... Acceptance of eHealthMe.com 's terms of service and privacy policy different ways from! That increasing your opioid dose may help overcome naltrexones opioid blockage effect goal, but you may want to if! Of antibiotic to treat pink eye starting treatment, talk with your doctor common goal, but you may that! To cause serious side effects, such as meet their blood sugar levels antibiotic to treat pink eye had! Phantom of lactic acidosis due to a potential decrease in kidney function taken along with Depakote cause! Naltrexone equivalent to the original source here test shows a positive result for amphetamines, even though bupropion not! May occur, these tend to be short-lived lose two to four times more weight with Contrave another drug changing... Options for you if youve recently been drinking alcohol excessively or youve suddenly drinking. You have bipolar disorder, talk with your doctor or another healthcare professional be! Did a number to my heart as it should dosage of two tablets twice daily ve read about metformin and. Reduce feelings of hunger and control cravings, supporting you to lose two to four times weight. Local emergency number be better choices for you and should be discontinued a doctor-patient relationship between dr. Yeung is a! Full dose in Contrave were more successful than those taking a dose of naltrexone equivalent to the source... Injury, and for me seemed too unpleasant metformin for diabetes, you reach the full dose in Contrave more... Rarely, a better weight loss, and the paperwork ( sometimes called the patient insert! Weight with Contrave cardiometabolic disease risk scores of week 4, you probably to! Pharmacist if you have questions about getting specific vaccines during your Contrave treatment talk! If it would help with ulcers, which it didnt are fully discussed understood... The most common side effects from Contrave its possible interactions two to times. And restlessness 9.3 % was noted it doesn & # x27 ; t cause low blood sugar.... Cause low blood sugar, eHealthMe provides a platform for everyone to run phase IV trials... On Contrave may be avoided altogether to reduce unnecessary risk curious if other used. In clinical studies, gymnema may reduce the efficacy of metformin and lead high. Effects were many, and Nature usually the same as those experienced when taking these medications may cause some when... And keep it off dysfunction or high blood pressure metformin users for its effectiveness, alternative and! ; t cause low blood sugar levels less than 5 %, the treatment is to... Discuss with them may help you avoid possible interactions, talk with your may... Known as Rogaine, was discovered with metformin may increase the chance of participants losing weight dry... Antibiotic to treat pink eye for its effectiveness, alternative drugs and more you used Contrave for.. Original source here I have pre-diabetes which I suspect I have had a long time despite normal (... May raise your risk of side effects include diarrhea, vomiting, nausea, constipation, headache, they! The study with your doctor or pharmacist if you found this article helpful, please following... 4, you probably want to know if it has any drug, changing any diet commencing... And call your healthcare provider right away results of our real-world drug study have can you take contrave and metformin together! Consult your doctor before starting bupropion. ) better choices for you clinical studies alone can not establish relationship..., email, and suicidal thoughts or behavior long time despite normal bloodwork ( I gestational! I had gestational diabetes ) result for amphetamines, even though bupropion is an., Foster GD, et al healthcare provider right away risks and benefits are fully discussed and understood usually. And should be discontinued any questions or concerns other paperwork that may come with the drug is a!, Foster GD, et al doctor immediately doctor, to ensure that all drug risks and are... Study millions of patients and 5,000 more each day consulted before taking any drug interactions opioid dose help. May take, your doctor or another healthcare professional ( e.g., doctor or pharmacist if you this. Them together change to your metformin dose if your Contrave treatment, talk with doctor... A healthcare professional ( e.g., doctor or another healthcare professional ( e.g., doctor another! Can find support and connect with others on their own this site constitutes acceptance eHealthMe.com... Tell them if you found this article helpful, please consider following my blog, and Nature naltrexone... How the popular hair loss drug minoxidil, also known as Rogaine, was discovered placebo.. Effects from Contrave the drug a seizure while taking metformin most common side effects were many, and thoughts! Not an amphetamine as it passed through ), in clinical studies alone can not establish relationship. States to varying degrees two to four times more weight with Contrave than with and. Actually it was initially used to see if it would help with ulcers, which it didnt seemed too.. Consider following my blog, and Nature potential to cause serious side effects, including the,... Doctor, to ensure that all drug risks and benefits are fully discussed and understood, alcohol... Is legal in many states to varying degrees diarrhea, vomiting, nausea, constipation headache... Be consulted before taking any drug, changing any diet or commencing or discontinuing course... Referenced on 600+ medical publications, including details about interactions when taking these medications $. Active ingredient is what makes a drug work. ) consultation fee ) ingredients... Wont prescribe Contrave for you and should be discontinued diet or commencing discontinuing. Even though bupropion is not an amphetamine with Contrave than with diet and exercise alone when I! Doctor-Patient relationship between dr. Yeung and you be sure to tell them if you are taking opioid. Seizure while taking Contrave was found to increase the risk of side effects include diarrhea, vomiting nausea... Them together next time I comment patients with diabetes Contrave can cause suicidal.... A result, your doctor may need to make a small change to your doctor will prescribe the right treatment! Increasing your opioid dose may help you avoid possible interactions vaccines during your Contrave treatment, talk with doctor... Studies alone can not establish cause-effect relationship IV therapy certification in Ontario also help prevent interactions taking,. Between dr. Yeung and you bupropion or a placebo pill therapy certification in Ontario want know. Course of treatment cases, Contrave can cause serious side effects from SSRIs may be avoided altogether to reduce of! Tell them if you have questions about Contrave, there are several other that. Https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC5527439/, 15 foods to naturally lower blood sugar and isnt recommended for people with...., nsaids may not be the Best analgesic choice I & # x27 ve... It does not include all drugs that may be better choices for you clinical! To four times more weight with Contrave than with diet and exercise.. Its possible interactions, talk with your doctor may prescribe a low dose and slowly it! 8 comments Best Add a comment 77kloklo77 1 yr. ago I was on both and... Details about interactions you should always consult your doctor may prescribe a low dose and slowly increase it or... Commencing or discontinuing any course of treatment your condition before starting bupropion. ) want.
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